Ursodioldosage

Recommended adult dosage: 13 to 15 mg/kg/day administered in two to four divided doses with food. Scored ursodiol 500 mg tablet: scored tablet can be broken in halves to provide recommended dosage.

2.1 General

Dosing Information The recommended adult dosage for ursodiol tablets in the treatment of PBC is 13 to 15 mg/kg/day administered in two to four divided doses with food. Dosing regimen should be adjusted according to each patient’s need at the discretion of the physician.

2.2 Liver Function

Tests Liver function tests ( γ-GT, alkaline phosphatase, AST, ALT) and bilirubin levels should be monitored every month for three months after start of therapy, and every six months thereafter.

2.3 Scoring the

Ursodiol Tablets 500 mg The ursodiol 500 mg scored tablet can be broken in halves to provide recommended dosage. To break ursodiol 500 mg scored tablet easily, place the tablet on a flat surface with the scored section on top. Hold the tablet with your thumbs placed close to the scored part of the tablet (groove). Then apply gentle pressure and snap the tablet segments apart (segments breaking incorrectly should not be used). The segments should be washed down unchewed, with water, keeping the segments in the mouth can reveal a bitter taste. Due to the bitter taste, segments should be stored separately from whole tablets..