Solifenacindosage
solifenacin succinate 10 MG Oral Tablet [Vesicare]
Dosage and administration
5 mg tablet taken orally once daily, and if well tolerated may be increased to 10 mg once daily.
Do not exceed the 5 mg dose of VESIcare in patients with: o Severe renal impairment creatinine clearance < 30 mL/min/1.73 m 2. o Moderate hepatic impairment (Child-Pugh B). VESIcare is not recommended in patients with severe hepatic impairment (Child-Pugh C). o Concomitant use of strong CYP3A4 inhibitors.
2.1 Dosing Information
The recommended oral dose of VESIcare is 5 mg once daily. If the 5 mg dose is well tolerated, the dose may be increased to 10 mg once daily. VESIcare should be taken with water and swallowed whole. VESIcare can be administered with or without food.
2.2 Dosing Recommendations in
Patients with Renal Impairment Do not exceed 5 mg once daily in patients with severe renal impairment (CL cr < 30 mL/min/1.73 m 2 ).
2.3 Dosing Recommendations in
Patients with Hepatic Impairment Do not exceed 5 mg once daily in patients with moderate hepatic impairment (Child-Pugh B). Do not use VESIcare in patients with severe hepatic impairment (Child-Pugh C).
2.4 Dosing Recommendations in
Patients Taking CYP3A4 Inhibitors Do not exceed 5 mg once daily when VESIcare is administered with strong CYP3A4 inhibitors such as ketoconazole.
Text above is quoted in full from the FDA-approved drug label published by openFDA, effective October 31, 2022. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.
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