Sitagliptindosage

The recommended dosage of Sitagliptin Tablets is 100 mg orally once daily. Sitagliptin Tablets can be taken with or without food. Dosage adjustment is recommended for patients with eGFR less than 45 mL/min/1.73 m 2. Dosage Adjustment in Patients with Renal Impairment eGFR greater than or equal to 30 mL/min/1.73 m 2 to less than 45 mL/min/1.73 m 2 eGFR less than 30 mL/min/1.73 m 2 (including patients with end stage renal disease [ESRD] on dialysis) 50 mg once daily 25 mg once daily

2.1 Recommended

Dosage The recommended dosage of Sitagliptin Tablets is 100 mg orally once daily. Sitagliptin Tablets can be taken with or without food.

2.2 Recommendations for

Use in Renal Impairment Assess renal function prior to initiation of Sitagliptin Tablets and periodically thereafter. For patients with an estimated glomerular filtration rate [eGFR] greater than or equal to 45 mL/min/1.73 m 2 to less than 90 mL/min/1.73 m 2, no dosage adjustment for Sitagliptin Tablets is required. For patients with moderate renal impairment (eGFR greater than or equal to 30 mL/min/1.73 m 2 to less than 45 mL/min/1.73 m 2 ), the dosage of Sitagliptin Tablets is 50 mg once daily. For patients with severe renal impairment (eGFR less than 30 mL/min/1.73 m 2 ) or with end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis, the dosage of Sitagliptin Tablets is 25 mg once daily. Sitagliptin Tablets may be administered without regard to the timing of dialysis.