Sertralinedosage

Do not initiate treatment with sertraline hydrochloride capsules. Use another sertraline hydrochloride product for initial dosage, titration, and dosages below 150 mg once daily Recommended dosage is 150 mg or 200 mg once daily Maximum recommended dosage is 200 mg once daily Swallow capsules whole. Do not open, crush, or chew When discontinuing sertraline hydrochloride capsules, reduce dose gradually whenever possible. Gradual dosage reduction will require use of another sertraline hydrochloride product

2.1 Dosage in

Patients with MDD and OCD Do not initiate treatment with sertraline hydrochloride capsules because the only available dose strengths are 150 mg and 200 mg. Use another sertraline hydrochloride product for initial dosage, titration, and dosages below 150 mg once daily. Refer to Prescribing Information of the other sertraline hydrochloride products for the recommended dosage for those products. Sertraline hydrochloride capsules can be initiated in patients receiving 100 mg or 125 mg of sertraline hydrochloride for at least one week. The recommended dosage of sertraline hydrochloride capsules is 150 mg or 200 mg once daily. The maximum recommended dosage is 200 mg once daily.

2.2 Administration

Instructions Administer sertraline hydrochloride capsules orally. Swallow capsules whole; do not open, crush, or chew.

2.3 Screen for

Bipolar Disorder Prior to Starting sertraline hydrochloride capsules Prior to initiating treatment with sertraline hydrochloride capsules or another antidepressant, screen patients for a personal or family history of bipolar disorder, mania, or hypomania.

2.4 Switching

Patients to or from a Monoamine Oxidase Inhibitor Antidepressant At least 14 days must elapse between discontinuation of a monoamine oxidase inhibitor (MAOI) antidepressant and initiation of sertraline hydrochloride capsules. In addition, at least 14 days must elapse after stopping sertraline hydrochloride capsules before starting an MAOI antidepressant.

2.5 Discontinuation of

Treatment with sertraline hydrochloride capsules Adverse reactions may occur upon discontinuation of sertraline hydrochloride capsules. Gradually reduce the dosage rather than stopping sertraline hydrochloride capsules abruptly whenever possible. Given that dosage strengths lower than 150 mg of sertraline hydrochloride capsules are not available, gradual dosage reduction will require the use of another sertraline hydrochloride product.