Modafinildosage

The recommended dosage of PROVIGIL for each indication is as follows: Narcolepsy or OSA: 200 mg once a day in the morning.

SWD: 200 mg once a day, taken approximately one hour prior to start of the work shift.

Severe Hepatic Impairment: reduce dose to half the recommended dose.

Geriatric Patients: consider lower dose.

2.1 Dosage in

Narcolepsy and Obstructive Sleep Apnea (OSA) The recommended dosage of PROVIGIL for patients with narcolepsy or OSA is 200 mg taken orally once a day as a single dose in the morning. Doses up to 400 mg/day, given as a single dose, have been well tolerated, but there is no consistent evidence that this dose confers additional benefit beyond that of the 200 mg/day dose.

2.2 Dosage in

Shift Work Disorder (SWD) The recommended dosage of PROVIGIL for patients with SWD is 200 mg taken orally once a day as a single dose approximately 1 hour prior to the start of their work shift.

2.3 Dosage Modifications in

Patients with Severe Hepatic Impairment In patients with severe hepatic impairment, the dosage of PROVIGIL should be reduced to one-half of that recommended for patients with normal hepatic function.

2.4 Use in Geriatric

Patients Consideration should be given to the use of lower doses and close monitoring in geriatric patients.