Memantinedosage

The recommended starting dose of memantine hydrochloride oral solution is 5 mg (2.5 mL) once daily. The dose should be increased in 5 mg increments to 10 mg/day (2.5 mL twice daily), 15 mg/day (2.5 mL and 5 mL as separate doses), and 20 mg/day (5 mL twice daily). The minimum recommended interval between dose increases is one week. The dosage shown to be effective in controlled clinical trials is 20 mg/day (5 mL twice daily). Dosing Titration Schedule Total daily dose Strength per dose (mg) Starting Dose 5 mg 5 mg Dose after week 1 10 mg 5 mg (first daily dose) 5 mg (second daily dose) Dose after week 2 15 mg 5 mg (first daily dose) 10 mg (second daily dose) Dose after week 3 20 mg 10 mg (first daily dose) 10 mg (second daily dose) Memantine hydrochloride oral solution can be taken with or without food. If a patient misses a single dose of memantine hydrochloride oral solution, that patient should not double up on the next dose. The next dose should be taken as scheduled. If a patient fails to take memantine hydrochloride oral solution for several days, dosing may need to be resumed at lower doses and retitrated as described above. Do not mix memantine hydrochloride oral solution with any other liquid. Memantine hydrochloride oral solution is administered with a plastic dispensing syringe and a press-in bottle adapter. The supplied syringe should be used to withdraw the correct volume of oral solution and the oral solution should be slowly squirted into the corner of the patient's mouth. May be taken with or without food Initial dose is 5 mg (2.5 mL) once daily. Increase dose in 5 mg increments to a maintenance dose of 10 mg (5 mL) twice daily. A minimum of 1 week of treatment with the previous dose should be observed before increasing the dose.

Severe renal impairment: recommended dose is 5 mg (2.5 mL) twice daily. Special Populations Renal Impairment A target dose of 5 mg (2.5 mL) twice daily is recommended in patients with severe renal impairment (creatinine clearance of 5 to 29 mL/min based on the Cockcroft-Gault equation). Hepatic Impairment Memantine hydrochloride oral solution should be administered with caution to patients with severe hepatic impairment.