Lopinavirdrug info
lopinavir 200 MG / ritonavir 50 MG Oral Tablet
What it is used for
Lopinavir and ritonavir is indicated in combination with other antiretroviral agents for the treatment of HIV1 infection in adults and pediatric patients 14 days and older.
Limitations of Use: Genotypic or phenotypic testing and/or treatment history should guide the use of lopinavir and ritonavir. The number of baseline lopinavir resistance-associated substitutions affects the virologic response to lopinavir and ritonavir. Lopinavir and ritonavir is an HIV-1 protease inhibitor indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients (14 days and older).
Text above is quoted in full from the FDA-approved drug label published by openFDA, effective June 5, 2021. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.
Description
Lopinavir and ritonavir tablets is a co-formulation of lopinavir and ritonavir. Lopinavir is an inhibitor of the HIV-1 protease. As co-formulated in lopinavir and ritonavir, ritonavir inhibits the CYP3A-mediated metabolism of lopinavir, thereby providing increased plasma levels of lopinavir. Lopinavir, USP is chemically designated as [1S-[1R*,(R*), 3R*, 4R*]]-N-[4-[[(2,6dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-alpha(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide. Its molecular formula is C37H48N4O5, and its molecular weight is 628.80. Lopinavir is a white to light tan powder. It is freely soluble in methanol and ethanol, soluble in isopropanol and practically insoluble in water. Lopinavir has the following structural formula: Ritonavir, USP is chemically designated as 10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-2,4,7,12-tetraazatridecan-13-oic acid, 5-thiazolylmethyl ester, [5S-(5R*,8R*,10R*,11R*)]. Its molecular formula is C37H48N6O5S2, and its molecular weight is 720.95. Ritonavir is a white to light tan powder. It is freely soluble in methanol and ethanol, soluble in isopropanol and practically insoluble in water. Ritonavir has the following structural formula: Lopinavir and ritonavir tablets, USP are available for oral administration in two strengths: Yellow tablets containing 200 mg of lopinavir and 50 mg of ritonavir Pale yellow tablets containing 100 mg of lopinavir and 25 mg of ritonavir. The yellow, 200 mg lopinavir and 50 mg ritonavir, tablets contain the following inactive ingredients: copovidone, sorbiton monolaurate, colloidal silicon dioxide, anhydrous dibasic calcium phosphate, sodium stearyl fumarate. The coating consists of titanium dioxide, polyethylene glycol 3350, talc, iron oxide yellow. The pale yellow, 100 mg lopinavir and 25 mg ritonavir, tablets contain the following inactive ingredients: copovidone, sorbiton monolaurate, colloidal silicon dioxide, anhydrous dibasic calcium phosphate, sodium stearyl fumarate. The coating consists of titanium dioxide, polyethylene glycol 3350, talc, iron oxide yellow. str-rito str-lopi
Text above is quoted in full from the FDA-approved drug label published by openFDA, effective June 5, 2021. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.
This page reproduces regulatory text for reference. It is not medical advice, and KenyRx is not a pharmacy or a prescriber. Talk to a doctor or pharmacist about whether a medicine is right for you.
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