Fluticasonedosage

Fluticasone propionate and salmeterol inhalation powder should be administered as 1 inhalation twice daily by the orally inhaled route only. After inhalation, the patient should rinse his/her mouth with water without swallowing to help reduce the risk of oropharyngeal candidiasis. More frequent administration or a greater number of inhalations (more than 1 inhalation twice daily) of the prescribed strength of fluticasone propionate and salmeterol inhalation powder is not recommended as some patients are more likely to experience adverse effects with higher doses of salmeterol. Patients using fluticasone propionate and salmeterol inhalation powder should not use additional LABA for any reason.

For oral inhalation only.

Treatment of Asthma in Patients Aged 12 Years and Older: 1 inhalation of fluticasone propionate and salmeterol inhalation powder 100 mcg/50 mcg, fluticasone propionate and salmeterol inhalation powder 250 mcg/50 mcg, or fluticasone propionate and salmeterol inhalation powder 500 mcg/50 mcg twice daily. Starting dosage is based on asthma severity.

Treatment of Asthma in Patients Aged 4 to 11 Years: 1 inhalation of fluticasone propionate and salmeterol inhalation powder 100 mcg/50 mcg twice daily.

Maintenance Treatment of COPD: 1 inhalation of fluticasone propionate and salmeterol inhalation powder 250 mcg/50 mcg twice daily. 2.1 Asthma If asthma symptoms arise in the period between doses, an inhaled, short-acting beta 2 -agonist should be taken for immediate relief. Adult and Adolescent Patients Aged 12 Years and Older For patients aged 12 years and older, the dosage is 1 inhalation twice daily, approximately 12 hours apart. When choosing the starting dosage strength of fluticasone propionate and salmeterol inhalation powder, consider the patients’ disease severity, based on their previous asthma therapy, including the ICS dosage, as well as the patients’ current control of asthma symptoms and risk of future exacerbation. The maximum recommended dosage is fluticasone propionate and salmeterol inhalation powder 500 mcg/50 mcg twice daily. Improvement in asthma control following inhaled administration of fluticasone propionate and salmeterol inhalation powder can occur within 30 minutes of beginning treatment, although maximum benefit may not be achieved for 1 week or longer after starting treatment. Individual patients will experience a variable time to onset and degree of symptom relief. For patients who do not respond adequately to the starting dosage after 2 weeks of therapy, replacing the current strength of fluticasone propionate and salmeterol inhalation powder with a higher strength may provide additional improvement in asthma control. If a previously effective dosage regimen fails to provide adequate improvement in asthma control, the therapeutic regimen should be reevaluated and additional therapeutic options (e.g., replacing the current strength of fluticasone propionate and salmeterol inhalation powder with a higher strength, adding additional ICS, initiating oral corticosteroids) should be considered. Pediatric Patients Aged 4 to 11 Years For patients with asthma aged 4 to 11 years who are not controlled on an ICS, the dosage is 1 inhalation of fluticasone propionate and salmeterol inhalation powder 100 mcg/50 mcg twice daily, approximately 12 hours apart.

2.2 Chronic

Obstructive Pulmonary Disease The recommended dosage for patients with COPD is 1 inhalation of fluticasone propionate and salmeterol inhalation powder 250 mcg/50 mcg twice daily, approximately 12 hours apart. If shortness of breath occurs in the period between doses, an inhaled, short-acting beta 2 -agonist should be taken for immediate relief.