Ertugliflozindosage

Assess renal function before initiating and as clinically indicated. Correct volume depletion before initiating STEGLATRO. Recommended starting dosage is 5 mg orally once daily, taken in the morning, with or without food. Increase dosage to 15 mg orally once daily in those tolerating STEGLATRO and needing additional glycemic control. Use is not recommended in patients with an estimated glomerular filtration rate (eGFR) less than 45 mL/min/1.73 m 2. Withhold STEGLATRO for at least 4 days, if possible, prior to surgery or procedures associated with prolonged fasting.

2.1 Prior to

Initiation of STEGLATRO Assess renal function before initiating STEGLATRO and as clinically indicated. Assess volume status. In patients with volume depletion, correct this condition before initiating STEGLATRO.

2.2 Recommended

Dosage The recommended starting dosage of STEGLATRO is 5 mg orally once daily, taken in the morning, with or without food. For additional glycemic control, the dosage may be increased to 15 mg orally once daily in patients tolerating STEGLATRO. Use of STEGLATRO is not recommended in patients with an estimated glomerular filtration rate (eGFR) less than 45 mL/min/1.73 m 2.

2.3 Temporary

Interruption for Surgery Withhold STEGLATRO for at least 4 days, if possible, prior to surgery or procedures associated with prolonged fasting. Resume STEGLATRO when the patient is clinically stable and has resumed oral intake.

2.4 Recommendations

Regarding Missed Dose If a dose is missed, instruct patients to take the dose as soon as possible. Advise patients not to double up the next dose.