Doxycyclineinteractions
doxycycline hyclate 200 MG Delayed Release Oral Tablet
This is the interactions section of this product’s FDA label — what the manufacturer documented for this drug. It is not a check of your medication list, and a drug missing from it has not been cleared: licensed clinical databases list far more interactions than any single label does. Before combining medicines, ask a pharmacist, who can check everything you take at once and will do it for free.
Named on this label
Every name above is printed in the text below. This is not the full set of drugs that interact with this one — it is the set this manufacturer wrote down.
Drug interactions
Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage
Avoid co-administration of tetracyclines with penicillin
Absorption of tetracyclines, including doxycycline hyclate delayed-release tablets, is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron-containing preparations
Concurrent use of tetracyclines, including doxycycline hyclate delayed-release tablets, may render oral contraceptives less effective
Barbiturates, carbamazepine and phenytoin decrease the half-life of doxycycline
7.1 Anticoagulant
Drugs Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
7.2 Penicillin
Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin.
7.3 Antacids and
Iron Preparations Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate, and iron-containing preparations.
7.4 Oral Contraceptives
Concurrent use of tetracycline may render oral contraceptives less effective.
7.5 Barbiturates and
Anti-Epileptics Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.
7.6 Drug/Laboratory
Test Interactions False elevations of urinary catecholamines may occur due to interference with the fluorescence test.
Text above is quoted in full from the FDA-approved drug label published by openFDA, effective October 31, 2025. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.
This page reproduces regulatory text for reference. It is not medical advice, and KenyRx is not a pharmacy or a prescriber. Talk to a doctor or pharmacist about whether a medicine is right for you.
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