Digoxindrug info
digoxin 0.125 MG Oral Tablet
What it is used for
Digoxin is a cardiac glycoside indicated for: Treatment of mild to moderate heart failure in adults. Increasing myocardial contractility in pediatric patients with heart failure. Control of resting ventricular rate in patients with chronic atrial fibrillation in adults.
1.1 Heart Failure in
Adults Digoxin tablets are indicated for the treatment of mild to moderate heart failure in adults. Digoxin tablets increases left ventricular ejection fraction and improves heart failure symptoms as evidenced by improved exercise capacity and decreased heart failure-related hospitalizations and emergency care, while having no effect on mortality. Where possible, digoxin tablets should be used in combination with a diuretic and an angiotensin-converting enzyme (ACE) inhibitor.
1.2 Heart Failure in
Pediatric Patients Digoxin tablets increases myocardial contractility in pediatric patients with heart failure.
1.3 Atrial Fibrillation in
Adults Digoxin tablets are indicated for the control of ventricular response rate in adult patients with chronic atrial fibrillation.
Text above is quoted in full from the FDA-approved drug label published by openFDA, effective July 11, 2024. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.
Description
Digoxin is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants. Digoxin is extracted from the leaves of Digitalis lanata. The term “digitalis” is used to designate the whole group of glycosides. The glycosides are composed of 2 portions: a sugar and a cardenolide (hence “glycosides”). Digoxin is described chemically as (3β,5β,12β)-3-[( O -2,6-dideoxy-β- D-ribo -hexopyranosyl-(1→4)- O -2,6-dideoxy-β- D-ribo- hexopyranosyl-(1→4)-2,6-dideoxy-β- D - ribo- hexopyranosyl)oxy]-12,14-dihydroxy-card-20-enolide. Its molecular formula is C 41 H 64 O 14, its molecular weight is 780.95, and its structural formula is: Digoxin USP exists as clear to white, crystals or white crystalline powder that melt with decomposition above 230°C. The drug is practically insoluble in water, soluble in a mixture of equal volumes of methanol and methylene chloride, slightly soluble in ethanol (96 per cent). Digoxin tablets, USP are supplied as 62.5 mcg (unscored), 125 mcg (scored) and 250 mcg (scored) tablets for oral administration. Each tablet contains the labeled amount of digoxin USP and the following inactive ingredients: corn starch, lactose monohydrate, magnesium stearate and pregelatinized starch (maize). In addition the 62.5 mcg tablets contain FD & C Yellow No. 6 Lake. FDA approved dissolution test specifications differ from USP. Chemical Structure
Text above is quoted in full from the FDA-approved drug label published by openFDA, effective July 11, 2024. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.
This page reproduces regulatory text for reference. It is not medical advice, and KenyRx is not a pharmacy or a prescriber. Talk to a doctor or pharmacist about whether a medicine is right for you.
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