Clonidinedosage

Starting dosage is 0.1 mg of ONYDA XR orally once daily at bedtime with or without food. Dosage may be increased in increments of 0.1 mg per day at weekly intervals. Maximum recommended dosage is 0.4 mg once daily at bedtime. Do not substitute ONYDA XR for other clonidine products on a mg-per-mg basis because of differing pharmacokinetic profiles. When discontinuing, taper the dose in decrements of no more than 0.1 mg every 3 to 7 days to avoid rebound hypertension.

2.1 Recommended

Dosage The starting dosage of ONYDA XR is 0.1 mg orally once daily at bedtime with or without food. Titrate the dose of ONYDA XR in increments of 0.1 mg per day at weekly intervals depending on clinical response up to the maximum recommended dosage of 0.4 mg once daily at bedtime. Doses of ONYDA XR higher than 0.4 mg once daily were not evaluated in clinical trials for ADHD and are not recommended. When ONYDA XR is added to a CNS stimulant, adjust the dose of the CNS stimulant depending on the clinical response to ONYDA XR.

2.2 Administration

Instructions Instruct patients to read the “Instructions for Use” for complete administration instructions. Use the oral dosing dispenser and bottle adapter provided with ONYDA XR. Ensure that the bottle adapter is firmly inserted into the bottle before first use and keep the adapter in place for the duration of the usage of the bottle. Gently shake ONYDA XR with a smooth up and down motion (to avoid foaming) for at least 10 seconds before each administration. For the bottles of 30 mL and 60 mL, discard any unused ONYDA XR 30 days after first opening the bottle. For the 120 mL bottle, discard any unused ONYDA XR 60 days after first opening the bottle.

2.3 Switching from

Other Clonidine Products For patients switching from another clonidine product, discontinue that treatment, and titrate with ONYDA XR using the titration schedule. Do not substitute for other clonidine products on a milligram-per-milligram basis because of differing pharmacokinetic profiles.

2.4 Discontinuation

When discontinuing ONYDA XR, taper the total daily dose in decrements of no more than 0.1 mg every 3 to 7 days to avoid rebound hypertension.

2.5 Missed Doses

If a dose of ONYDA XR is missed, skip that dose and take the next dose as scheduled. Do not take more than the prescribed total daily amount of ONYDA XR in any 24-hour period.