Azilsartandosage

Starting dose is 40/12.5 mg once daily Edarbyclor may be used to provide additional blood pressure lowering for patients not adequately controlled on azilsartan medoxomil 80 mg or chlorthalidone 25 mg Dose may be increased to 40/25 mg after 2 to 4 weeks as needed to achieve blood pressure goals Maximal dose is 40/25 mg May be administered with other antihypertensive agents Edarbyclor may be administered with or without food Replace volume in volume-depleted patients prior to use

2.1 Dosing Information

The recommended starting dose of Edarbyclor is 40/12.5 mg taken orally once daily. Most of the antihypertensive effect is apparent within 1 to 2 weeks. The dosage may be increased to 40/25 mg after 2 to 4 weeks as needed to achieve blood pressure goals. Edarbyclor doses above 40/25 mg are probably not useful. Patients titrated to the individual components (azilsartan medoxomil and chlorthalidone) may instead receive the corresponding dose of Edarbyclor. Edarbyclor may be administered with other antihypertensive agents as needed.

2.2 Prior to

Dosing Correct any volume depletion prior to administration of Edarbyclor, particularly in patients with impaired renal function or those treated with high doses of diuretics. Patients who experience dose-limiting adverse reactions on chlorthalidone may be switched to Edarbyclor, initially with a lower dose of chlorthalidone.

2.3 Handling

Instructions Do not repackage Edarbyclor. Dispense and store Edarbyclor in its original container to protect Edarbyclor from light and moisture.