Avanafildosage

The starting dose is 100 mg taken as early as approximately 15 minutes before sexual activity, on an as needed basis

Take avanafil tablet no more than once a day.

Based on efficacy and/or tolerability, the dose may be increased to 200 mg taken as early as approximately 15 minutes before sexual activity or decreased to 50 mg taken approximately 30 minutes before sexual activity. Use the lowest dose that provides benefit.

Avanafil tablet may be taken with or without food

Do not use avanafil tablet with strong CYP3A4 inhibitors

If taking a moderate CYP3A4 inhibitor, the dose should be no more than 50 mg in a 24-hour period.

In patients on stable alpha-blocker therapy, the recommended starting dose of avanafil tablet is 50 mg.

2.1 Erectile

Dysfunction The recommended starting dose is 100 mg. Avanafil tablets should be taken orally as needed as early as approximately 15 minutes before sexual activity. Based on individual efficacy and tolerability, the dose may be increased to 200 mg taken as early as approximately 15 minutes before sexual activity, or decreased to 50 mg taken approximately 30 minutes before sexual activity. The lowest dose that provides benefit should be used. The maximum recommended dosing frequency is once per day. Sexual stimulation is required for a response to treatment.

2.2 Use with

Food Avanafil tablets may be taken with or without food.

2.3 Concomitant

Medications Nitrates Concomitant use of nitrates in any form is contraindicated. Alpha-Blockers If avanafil tablet is co-administered with an alpha-blocker, patients should be stable on alpha-blocker therapy prior to initiating treatment with avanafil tablet, and avanafil tablet should be initiated at the 50 mg dose. CYP3A4 Inhibitors

For patients taking concomitant strong CYP3A4 inhibitors (including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin), do not use avanafil tablet.

For patients taking concomitant moderate CYP3A4 inhibitors (including erythromycin, amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir, and verapamil), the maximum recommended dose of avanafil tablet is 50 mg, not to exceed once every 24 hours.