Atorvastatindosage

Take orally once daily with or without food.

Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating LIPITOR, and adjust dosage if necessary.

Adults: o Recommended starting dosage is 10 or 20 mg once daily; dosage range is 10 mg to 80 mg once daily. o Patients requiring LDL-C reduction >45% may start at 40 mg once daily.

Pediatric Patients Aged 10 Years of Age and Older with HeFH: Recommended starting dosage is 10 mg once daily; dosage range is 10 to 20 mg once daily.

Pediatric Patients Aged 10 Years of Age and Older with HoFH: Recommended starting dosage is 10 to 20 mg once daily; dosage range is 10 to 80 mg once daily.

See full prescribing information for LIPITOR dosage modifications due to drug interactions.

2.1 Important

Dosage Information

Take Lipitor orally once daily at any time of the day, with or without food.

Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating LIPITOR, and adjust the dosage if necessary.

If a dose is missed, advise patients not to take the missed dose and resume with the next scheduled dose.

2.2 Recommended

Dosage in Adult Patients The recommended starting dosage of LIPITOR is 10 mg to 20 mg once daily. The dosage range is 10 mg to 80 mg once daily. Patients who require reduction in LDL-C greater than 45% may be started at 40 mg once daily.

2.3 Recommended

Dosage in Pediatric Patients 10 Years of Age and Older with HeFH The recommended starting dosage of LIPITOR is 10 mg once daily. The dosage range is 10 mg to 20 mg once daily.

2.4 Recommended

Dosage in Pediatric Patients 10 Years of Age and Older with HoFH The recommended starting dosage of LIPITOR is 10 mg to 20 mg once daily. The dosage range is 10 mg to 80 mg once daily.

2.5 Dosage Modifications

Due to Drug Interactions Concomitant use of LIPITOR with the following drugs requires dosage modification of LIPITOR. Anti-Viral Medications

In patients taking saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, fosamprenavir plus ritonavir, elbasvir plus grazoprevir or letermovir, do not exceed LIPITOR 20 mg once daily.

In patients taking nelfinavir, do not exceed LIPITOR 40 mg once daily. Select Azole Antifungals or Macrolide Antibiotics

In patients taking clarithromycin or itraconazole, do not exceed LIPITOR 20 mg once daily. For additional recommendations regarding concomitant use of LIPITOR with other anti-viral medications, azole antifungals or macrolide antibiotics, see Drug Interactions.