Amoxicillindosage

Adults and Pediatric Patients weighing greater than or equal to 40 kg who are able to swallow tablets: The recommended dosage of Amoxicillin and Clavulanate Potassium Extended Release Tablets is 4,000 mg/250 mg daily in divided doses at the start of a meal according to the following table. Indication Dose Duration Acute bacterial sinusitis Two (1,000 mg/62.5 mg) tablets every 12 hours 10 days Community-acquired pneumonia Two (1,000 mg/62.5 mg) tablets every 12 hours 7 to 10 days

2.1 Important

Administration Instructions Amoxicillin and Clavulanate Potassium Extended Release Tablets should be taken at the start of a meal to enhance the absorption of amoxicillin and to minimize the potential for gastrointestinal intolerance. Amoxicillin and Clavulanate Potassium Extended Release Tablets is not recommended to be taken with a high-fat meal because clavulanate absorption is decreased.

2.2 Dosage in

Adults Patients The recommended dosage of Amoxicillin and Clavulanate Potassium Extended Release Tablets is 4,000 mg/250 mg daily in divided doses according to the following table: Table 1: Recommended Dosage of Amoxicillin and Clavulanate Potassium Extended Release Tablets in Adult Patients Indication Dose Duration Acute bacterial sinusitis Two (1,000 mg/62.5 mg) tablets every 12 hours 10 days Community-acquired pneumonia Two (1,000 mg/62.5 mg) tablets every 12 hours 7 to 10 days Amoxicillin and Clavulanate Potassium Extended Release Tablets can be split in half along the score line for patients with difficulty swallowing the tablets whole. Both halves of the tablet must be taken immediately.

2.3 Dosage in

Pediatric Patients Pediatric patients who weigh 40 kg or more and can swallow tablets should receive the adult dose.

2.4 Dosage in

Patients with Hepatic Impairment Hepatically impaired patients should be dosed with caution and hepatic function monitored at regular intervals.

2.5 Switching

Between Dosage Forms and Strengths Amoxicillin and Clavulanate Potassium Extended Release Tablets is NOT substitutable on a mg-to-mg basis with other formulations of Amoxicillin and Clavulanate. In addition, the extended-release tablets provide an extended time course of plasma amoxicillin concentrations compared to immediate-release tablets. Thus, two Amoxicillin and Clavulanate 500 mg tablets are not equivalent to one Amoxicillin and Clavulanate Potassium Extended Release Tablets 1,000 mg tablet.