Amitriptylinedrug info
amitriptyline hydrochloride 10 MG / perphenazine 2 MG Oral Tablet
What it is used for
Perphenazine and amitriptyline hydrochloride tablets are recommended for treatment of patients with moderate to severe anxiety and/or agitation and depressed mood, patients with depression in whom anxiety and/or agitation are severe, and patients with depression and anxiety in association with chronic physical disease. In many of these patients, anxiety masks the depressive state so that, although therapy with a tranquilizer appears to be indicated, the administration of a tranquilizer alone will not be adequate. Schizophrenic patients who have associated depressive symptoms should be considered for therapy with perphenazine and amitriptyline hydrochloride tablets.
Text above is quoted in full from the FDA-approved drug label published by openFDA, effective August 30, 2025. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.
Description
Perphenazine and amitriptyline hydrochloride, a broad spectrum psychotherapeutic agent for the management of outpatients and hospitalized patients with psychoses or neuroses characterized by mixtures of anxiety or agitation with symptoms of depression, is a combination of perphenazine and amitriptyline hydrochloride. Since such mixed syndromes can occur in patients with various degrees of intensity of mental illness, perphenazine and amitriptyline hydrochloride tablets are provided in multiple combinations to afford dosage flexibility for optimum management. Perphenazine is a phenothiazine derivative. The formula is 4-[3-(2-chloro-10 H -phenothiazin-10yl) propyl]-piperazineethanol. Perphenazine, USP is a white, odorless, bitter tasting powder that is insoluble in water. The molecular weight is 403.97.
Its structural formula is: Amitriptyline is a dibenzocycloheptadiene derivative. The formula is 10,11-dihydro- N, N -dimethyl-5 H -dibenzo[a,d]cycloheptene-∆ 5,γ -propylamine hydrochloride. Amitriptyline hydrochloride, USP is a white, odorless, crystalline compound which is freely soluble in water. The molecular weight is 313.87.
Its structural formula is: Each tablet for oral administration contains the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch (corn), sodium lauryl sulfate and titanium dioxide. The following additional product specific inactive ingredients are employed: 2 mg/10 mg - hydroxypropyl cellulose 2 mg/25 mg - hydroxypropyl cellulose 4 mg/10 mg - polysorbate 80 4 mg/25 mg - hydroxypropyl cellulose 4 mg/50 mg - hydroxypropyl cellulose The following product specific coloring agents are employed: 2 mg/10 mg - calcium sulfate, talc 2 mg/25 mg - D&C Red No. 7 Calcium Lake, FD&C Blue No. 1 Aluminum Lake 4 mg/10 mg - FD&C Blue No. 1 Aluminum Lake 4 mg/25 mg - FD&C Yellow No. 6 Aluminum Lake 4 mg/50 mg - D&C Red No. 7 Calcium Lake, FD&C Blue No. 1 Aluminum Lake Perphenazine Structural Formula Amitriptyline Structural Formula
Text above is quoted in full from the FDA-approved drug label published by openFDA, effective August 30, 2025. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.
This page reproduces regulatory text for reference. It is not medical advice, and KenyRx is not a pharmacy or a prescriber. Talk to a doctor or pharmacist about whether a medicine is right for you.
See what it costs — price without insurance