Alogliptindosage

The recommended dosage in patients with normal renal function or mild renal impairment is 25 mg orally once daily. Can be taken with or without food. Adjust dosage if moderate or severe renal impairment or end-stage renal disease (ESRD). Degree of Renal Impairment Creatinine Clearance (mL/min) Recommended Dosage Moderate ≥30 to <60 12.5 mg once daily Severe/ESRD <30 6.25 mg once daily

2.1 Recommended

Dosage The recommended dosage of NESINA is 25 mg taken orally once daily. Do not split tablets. NESINA may be taken with or without food. Instruct patients if a dose is missed, not to double their next dose.

2.2 Patients with

Renal Impairment Assess renal function prior to initiation of NESINA and periodically thereafter. No dose adjustment of NESINA is necessary for patients with mild renal impairment (creatinine clearance [CrCl] ≥60 mL/min). The dose of NESINA is 12.5 mg once daily for patients with moderate renal impairment (CrCl ≥30 to <60 mL/min). The dose of NESINA is 6.25 mg once daily for patients with severe renal impairment (CrCl ≥15 to <30 mL/min) or with end-stage renal disease (ESRD) (CrCl <15 mL/min or requiring hemodialysis). NESINA may be administered without regard to the timing of dialysis. NESINA has not been studied in patients undergoing peritoneal dialysis.